原著論文

  • Iwata W, Unoki-Kubota H, Kato H, Shimizu A, Matsumoto M, Imasawa T, Igarashi A, Matsumoto K, Noda T, Terauchi Y, Nangaku M, Kasuga M, Kaburagi Y.
    Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure.PLoS One.
    2020;15(3): e0229397. DOI: 10.1371/journal.pone.0229397.

  • Kaburagi Y, Takahashi E, Kajio H, Yamashita S, Yamamoto-Honda R, Shiga T, Okumura A, Goto A, Fukazawa Y, Seki N, Tobe K, Matsumoto M, Noda M, Unoki-Kubota H.
    Urinary afamin levels are associated with the progression of diabetic nephropathy.Diabetes Res Clin Pract.
    2019 147:37-46. DOI: 10.1016/j.diabres.2018.02.034.

  • Itai N, Shimazu T, Kimura T, Ibe I, Yamashita R, Kaburagi Y, Dohi T, Tonozuka T, Takao T, Nishikawa A.
    The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis.PLoS One.
    (2018) 13, e0207205. DOI: 10.1371/journal.pone.0207205.

  • Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Minami S, Kasuga M, Matsumoto M.
    PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimizing gluconeogenesis and insulin signaling in hepatocytes.
    Sci Rep. 2018 8(1):14290. DOI: 10.1038/s41598-018-32575-z

  • Mikamo H, Jiang M, Noro M, Suzuki Y, Hiruta N, Unoki-Kubota H, Schneider WJ, Bujo H.　
    Susceptibilities of epicardial and subcutaneous fat tissue for browning-gene expression and diet-induced volume reduction are different.
    Mol Med Rep. 2018 17:6542-6550. DOI:10.3892/mmr.2018.8690

  • Hiramoto M, Udagawa H, Ishibashi N, Takahashi E, Kaburagi Y, Miyazawa K, Funahashi N, Nammo T, Yasuda K.
    A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression.
    Int J Mol Med. 2017 Nov 20. DOI: 10.3892/ijmm.2017.3273　PMID: 29207083

  • Okumura A, Saito T, Tobiume M, Hashimoto Y, Sato Y, Umeyama T, Nagi M, Tanabe K, Unoki-Kubota H, Kaburagi Y, Hasegawa H, Miyazaki Y, Yamagoe S.
    Alleviation of lipopolysaccharide/d-galactosamine-induced liver injury in leukocyte cell-derived chemotaxin 2 deficient mice.Biochem Biophys Rep. 12, 166-171, 2017. DOI:10.1016/j.bbrep.2017.09.011. PMID:29090278

  • Takahashi E, Unoki-Kubota H, Shimizu Y, Okamura T, Iwata W, Kajio H, Yamamoto-Honda R, Shiga T, Yamashita S, Tobe K, Okumura A, Matsumoto M, Yasuda K, Noda M, Kaburagi Y.
    Proteomic analysis of serum biomarkers for pre-diabetes using the LEA rat, a spontaneous animal model of type 2 diabetes mellitus.
    J Diabetes Investig. 8(5):661-671, 2017. DOI:10.1111/jdi.12638　PMID:28150914

  • Sakai M, Tujimura-Hayakawa T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M.
    The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch.
    Nat Commun. 22;7:13147, 2016. DOI:10.1038/ncomms13147　PMID:27874008

  • Zheng H, Miyakawa T, Sawano Y, Asano A, Okumura A, Yamagoe S, Tanokura M.
    Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold.
    J Biol Chem. 291, 17133-17142, 2016. DOI:10.1074/jbc.M116.720375　PMID:27334921

  • Okumura A, Unoki-Kubota H,Takahashi E, Kaburagi Y.
    A novel angiogenic peptide, ΔADT: A truncated adrenotensin peptide revealed by secretory peptidome analysis of human retinal pericytes.
    BioScience Trends. NOV 13, 2016. DOI:10.5582/bst.2016.01189　PMID:27840371

  • Okumura A, Unoki-Kubota H, Yoshida-Hata N, Yamamoto-Honda R, Yamashita S, Iwata M, Tobe K, Kajio H, Noda M, Katai N, Yamagoe S, Kaburagi Y.Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy.
    Clin Chim Acta. 463:145-149, 2016. DOI:10.1016/j.cca.2016.10.031 　PMID:27816666

  • Okumura A, Unoki-Kubota H, Matsushita Y, Shiga T, Moriyoshi Y, Yamagoe S, Kaburagi Y.
    Increased serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in obesity and fatty liver.
    BioScience Trends. 7(6):276-83, 2013. DOI:10.5582/bst.2013.v7.6.276　PMID:24390366

  • Takahashi E, Okumura A,Unoki-Kubota H, Hirano H, Kasuga M, Kaburagi Y.
    Differential proteome analysis of serum proteins associated with the development of type 2 diabetes mellitus in the KK-Ay mouse model using the iTRAQ technique.
    J Proteomics. 84:40-51, 2013. DOI:10.1016/j.jprot.2013.03.014 　PMID:23545169

  • Okumura A, Suzuki T, Miyatake H, Okabe T, Hashimoto Y, Miyakawa T, Zheng H, Unoki-Kubota H, Ohno H, Dohmae N, Kaburagi Y, Miyazaki Y, Tanokura M, Yamagoe S.
    Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein.
    FEBS Lett. 587(5):404-9, 2013.DOI:10.1016/j.febslet.2013.01.025　PMID:23352894

  • Yokouchi H, Eto Koki, Nishimura W, Takeda N, Kaburagi Y, Yamamoto S, Yasuda K.
    Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells.
    Acta ophthalmologica. 91(4):e289-97, 2013. DOI:10.1111/aos.12097　PMID:23387337

  • Kaburagi Y, Unoki-Kubota H.
    Role of the podocyte signal transduction systems in the pathogenesis of diabetic nephropathy.
    Diabetology International. 2(4):160-161, 2011. DOI:10.1007/s13340-011-0053-8

  • Tanaka T, Sakurada S, Kano K, Takahashi E, Yasuda K, Hirano H, Kaburagi Y, Kobayashi N, Hang NT, Lien LT, Matsushita I ,Hijikata M, Uchida T, Keicho N.
    Identification of tuberculosis-associated proteins in whole blood supernatant.
    BMC Infect Dis.11:71, 2011. DOI:10.1186/1471-2334-11-71PMID:21418657

  • Takarabe D, Rokukawa Y, Takahashi Y, Goto A, Takaichi M, Okamoto M, Tsujimoto T, Noto H, Kishimoto M, Kaburagi Y, Yasuda K, Yamamoto-Honda R, Tsukada K, Honda M, Teruya K, Kajio H, Kikuchi Y, Oka S, Noda M.
    Autoimmune diabetes in HIV-infected patients on highly active antiretroviral therapy.
    J Clin Endocrinol Metab.. 95(8):4056-60, 2010. DOI:10.1210/jc.2010-0055　PMID:20484483

  • Unoki-Kubota H, Yamagishi S, Takeuchi M, Bujo H, Saito Y.
    Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice.
    Protein Pept Lett.. 17(9):1177-81, 2010. DOI:10.2174/092986610791760423　PMID:20441560

  • Maeda S, Kobayashi M, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DP, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura Y.
    A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes.
    PLoS Genet.. 6(2): e1000842, 2010. DOI:10.1371/Journal.pgen.1000842　PMID:20168990